In the present study, methanolic extract of Ipomoea reniformis herb (Underkani) (MEIR) in acute model of inflammation was assessed in rats. Administration of MEIR (200, 400 mg/kg, p.o.) exhibited significant anti-inflammatory activity. In acute inflammation as produced by Carrageenan 36.38% and 41.80% protection was observed. MEIR did not show any sign of toxicity and mortality up to a dose level of 1000 mg/kg, p.o. in rats. The results obtained suggest that the methanolic extract of Ipomoea reniformis herb (MEIR) is endowed with effective anti-inflammatory activity mediated via either by inhibition of cyclooxygenase cascade or by blocking the release of vasoactive substances (histamine, serotonin and kinins). These findings seem to justify the use of the plant in traditional Indian medicine in the treatment of inflammation, including arthritic conditions.
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